Serum interleukin-5 levels are elevated in mild and moderate persistent asthma irrespective of regular inhaled glucocorticoid therapy
| Autor: | Maries Joseph, Sheela Benedict, Wassef F. Safa, Jose Joseph |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
lcsh:RC705-779
Pulmonary and Respiratory Medicine business.industry lcsh:Diseases of the respiratory system medicine.disease atopic asthma Pathogenesis body regions Glucocorticoid therapy Immunology Non atopic Medicine inhaled steroids Interleukin-5 Atopic asthma business Persistent asthma Interleukin 5 non-atopic asthma Research Article Asthma |
| Zdroj: | BMC Pulmonary Medicine, Vol 4, Iss 1, p 2 (2004) BMC Pulmonary Medicine |
| ISSN: | 1471-2466 |
| DOI: | 10.1186/1471-2466-4-2 |
| Popis: | Background Interleukin-5 (IL-5) is thought to play a pivotal role in the pathogenesis of asthma. High levels of circulating IL-5 have been documented in acute asthma. However, serum IL-5 levels in mild to moderate asthmatics and the influence of regular use of inhaled glucocorticoids, is not known. Methods Fifty-six asthmatics and 56 age and sex matched controls were recruited prospectively from an outpatient department. Information on asthma severity and treatment was gathered by a questionnaire. Serum IL-5, total IgE and specific IgE levels were measured in a blinded fashion. Results There were 32 atopic and 24 non-atopic mild-to-moderate asthmatics. The median serum IL-5 levels in atopic asthmatics (9.5 pg/ml) and in non-atopic asthmatics (8.1 pg/ml) were significantly higher than in normal controls (4.4 pg/ml, both p < 0.003). However, median serum IL-5 levels in atopic and non-atopic asthmatics were not significantly different. The median serum IL-5 level was insignificantly higher in fourteen moderate persistent asthmatics (10.6 pg/ml) compared to forty-two mild persistent asthmatics (7.3 pg/ml) (p = 0.13). The median serum IL-5 levels in asthmatics using regular inhaled steroids (7.8 pg/ml) was not significantly different from those not using inhaled steroids (10.2 pg/ml). Furthermore, serum total IgE levels and eosinophil counts were not significantly different in those using versus those not using inhaled glucocorticoids. Conclusion Serum IL-5 levels are elevated in mild and moderate persistent atopic and non-atopic asthmatics. Regular use of inhaled glucocorticoids may not abrogate the systemic Th2 type of inflammatory response in mild-moderate persistent asthma. |
| Databáze: | OpenAIRE |
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