Chronic traumatic encephalopathy in an epilepsy surgery cohort
| Autor: | Melissa M. Blessing, Jeffrey W. Britton, Gregory D. Cascino, Joseph E. Parisi, Amy L. Jones |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pilot Projects tau Proteins Chronic Traumatic Encephalopathy Young Adult 03 medical and health sciences Epilepsy Postoperative Complications 0302 clinical medicine medicine Humans Epilepsy surgery Young adult Cognitive decline Retrospective Studies Cerebral Cortex business.industry Head injury Electroencephalography Retrospective cohort study Middle Aged medicine.disease Surgery Chronic traumatic encephalopathy 030104 developmental biology Frontal lobe Female France Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neurology. 90:e474-e478 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | ObjectiveTo determine the occurrence of chronic traumatic encephalopathy (CTE) in young adult patients undergoing epilepsy surgery.MethodsTen patients who underwent epilepsy surgery were randomly selected for this retrospective study. The patients were 18–45 years of age, had preoperative neuropsychological evaluation, and had 1 year postoperative follow-up. Microscopic sections from resections were evaluated for the presence of CTE with standard stains and antibodies to tau (clone AT8).ResultsThe median age at resection was 32.5 years (range 23–43) and the median duration of seizures was 23.5 years (range 3–28). Eight had a history of head injury. Preoperative neuropsychological testing showed mild to moderate cognitive impairment in 8 patients (80%). Pathologic examination in one patient showed focal sparse tau-immunoreactive lesions along descending rami and cortical gyral depths of the resected frontal lobe. Nine patients had no evidence of CTE. All focal cortical resections showed variable subpial and subcortical gliosis commonly identified in patients with chronic seizure disorders.ConclusionsThe present small retrospective observational study suggests that CTE may occur, but appears uncommon, in young adult patients undergoing surgical treatment for drug-resistant focal epilepsy. The significance of these findings requires further investigation to define the relative importance of tau accumulation in younger adult patients with drug-resistant focal epilepsy and cognitive decline. |
| Databáze: | OpenAIRE |
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