Self-emulsifying drug delivery system of black seed oil with improved hypotriglyceridemic effect and enhanced hepatoprotective function
| Autor: | Amena Islam, Shimul Halder, Syed Shabbir Haider, Md. Abdul Muhit, Manik Chandra Shill |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment Nigella sativa Medicine (miscellaneous) Self emulsifying Pharmacology 03 medical and health sciences 0404 agricultural biotechnology Nutraceutical Oral administration medicine TX341-641 Hypertriglyceridemia 030109 nutrition & dietetics Nutrition and Dietetics Black seed oil Chemistry Nutrition. Foods and food supply Self-emulsifying drug delivery system 04 agricultural and veterinary sciences medicine.disease Black seed 040401 food science Hepatoprotective Biopharmaceutical Drug delivery Food Science |
| Zdroj: | Journal of Functional Foods, Vol 78, Iss, Pp 104391-(2021) |
| ISSN: | 1756-4646 |
| Popis: | Black Seed Oil (BSO), obtained from the seeds of black cumin (Nigella sativa), has antioxidant, anti-inflammatory, and hepatoprotective effects. The present study was aimed to develop a self-emulsifying drug delivery system (SEDDS) of BSO, to improve hypotriglyceridemic and hepatoprotective function. SEDDS-BSO formed fine micelles with a mean droplet size of 183 nm and improved the dispersion behavior of BSO in water as evidenced by at least 2.6-fold higher dispersibility compared with BSO. In the CCl4-treated rat model of acute hepatic injury, SEDDS-BSO (10 mg-BSO/kg, p.o.) led to 91.7% and 86.8% reductions of alanine aminotransferase and aspartate aminotransferase, respectively, suggesting that SEDDS-BSO could attenuate hepatotoxicity compared to BSO. In addition, repeated oral administration of SEDDS-BSO (10 mg-BSO/kg, p.o.) for 7 days had a potent hypotriglyceridemic effect on rats with corn-oil-induced hypertriglyceridemia compared to BSO. Therefore, the SEDDS approach might be an efficacious dosage option to enhance the nutraceutical properties of BSO. |
| Databáze: | OpenAIRE |
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