Immunostimulatory activity of plumieride an iridoid in augmenting immune system by targeting Th-1 pathway in balb/c mice
| Autor: | Abid Hamid, Mytre Koul, Anpurna Kaul, Rachna D. Singh, Naresh Kumar Satti, Shashank K. Singh, Prabhu Dutt, Arem Qayum, Jasvinder Singh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Graft Rejection
0301 basic medicine Interleukin 2 Erythrocytes T-Lymphocytes medicine.medical_treatment Immunology Biology Pharmacology BALB/c 03 medical and health sciences 0302 clinical medicine Immune system Adjuvants Immunologic Immunity medicine Animals Tuberculosis Immunology and Allergy Hypersensitivity Delayed Spiro Compounds Antigens Furans Antibiotics Antitubercular Interleukin 4 B-Lymphocytes Mice Inbred BALB C Sheep Drug Synergism Mycobacterium tuberculosis Skin Transplantation biology.organism_classification 030104 developmental biology Cytokine 030220 oncology & carcinogenesis Humoral immunity Cyclosporine Macrophages Peritoneal Cytokines Female Tumor necrosis factor alpha Rifampin Spleen medicine.drug |
| Zdroj: | International Immunopharmacology. 48:203-210 |
| ISSN: | 1567-5769 |
| Popis: | Plumieride, an iridoid glucoside isolated from Plumieria acutifolia leaves was investigated for its immunostimulatory activity on humoral, cell mediated and intracellular cytokine levels in sensitized and unsensitised balb/c mice. Plumieride restores the suppressed cell mediated, humoral immune response and also enhances the release of TNF- α, IFN-γ, and IL-2 (Th-1) in immune compromised cyclosporine and cyclophosphamide treated balb/c mice. It does not stimulate the IL-4 (Th-2) expression. Plumieride demonstrates significant augmentation of Th-1 response in immunosuppressed balb/c mice. Results of the present study suggested that plumieride can be developed as an immunostimulatory adjuvant to treat the immune suppression in various disease condition(s). |
| Databáze: | OpenAIRE |
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