On receptors for estrogens (e2) and androgens (dht) in human endometrial carcinoma and ovarian tumours
| Autor: | J. P. Persijn, C. B. Korsten, L. G. Friberg, Stig Kullander |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Receptors
Steroid medicine.medical_specialty medicine.drug_class Stage ii Internal medicine Carcinoma Humans Medicine Ovarian tumours Receptor Cervical canal Progesterone Ovarian Neoplasms business.industry Obstetrics and Gynecology General Medicine Middle Aged medicine.disease medicine.anatomical_structure Endocrinology Receptors Estrogen Receptors Androgen Estrogen Uterine Neoplasms Dihydrotestosteron Cancer research Female business Hormone |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 57:261-264 |
| ISSN: | 1600-0412 0001-6349 |
| DOI: | 10.3109/00016347809154895 |
| Popis: | Some human endometrial carcinomas contain receptors for estrogen (E2) and dihydrotestosterone (DHT). Analysis of 50 primary endometrial carcinomas by agar gel electrophoresis revealed a varying receptor pattern, absence of both receptors, sole presence of E2- or DHT- receptor, or presence of both. Highly differentiated tumours often had receptors of both types (7/18) and poorly differentiated tumours most often lacked them (1/10). Primary tumours with metastases (Stages III-IV) seldom had combined receptors, only in 2 cases out of 9. Growth of the tumour down in the cervical canal (Stage II) implied absence of combined receptors in all of the 13 cases studied. In 8 different ovarian tumours, presence of either E2- or DHT-receptors was found in 6. The findings are discussed in relation to hormonal treatment of the disease. |
| Databáze: | OpenAIRE |
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