Synthesis and Characterization of the 'Sulfur-Rich' Bis(perthiobenzoato)(dithiobenzoato)technetium(III) Heterocomplex
| Autor: | Fiorenzo Refosco, Francesco Tisato, Franck Mevellec, Nicolas Noiret, Henri Patin, Alain Roucoux, Giuliano Bandoli |
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| Rok vydání: | 2002 |
| Předmět: |
Magnetic Resonance Spectroscopy
Chemical Phenomena Molecular Conformation TC-99M RADIOPHARMACEUTICALS chemistry.chemical_element Salt (chemistry) In Vitro Techniques Crystallography X-Ray Technetium Benzoates Catalysis Inorganic Chemistry CHEMISTRY Spectroscopy Fourier Transform Infrared Leukocytes CRYSTAL-STRUCTURE Physical and Theoretical Chemistry chemistry.chemical_classification Molecular Structure Sulfur Compounds Chemistry Physical Organotechnetium Compounds Sulfur Rhenium chemistry TECHNETIUM COMPLEXES BOND Oxidation-Reduction Nuclear chemistry |
| Zdroj: | Inorganic chemistry 41 (2002): 598–601. doi:10.1021/ic0107577 info:cnr-pdr/source/autori:Mevellec F. ; Tisato F. ; Refosco F. ; Roucoux A. ; Noiret N. ; Patin H. ; Bandoli G./titolo:Synthesis and characterization of the 'Sulfur-rich' bis(perthiobenzoato)(dithiobenzoato)technetium(III) heterocomplex/doi:10.1021%2Fic0107577/rivista:Inorganic chemistry/anno:2002/pagina_da:598/pagina_a:601/intervallo_pagine:598–601/volume:41 |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/ic0107577 |
| Popis: | The diamagnetic sulfur-rich technetium(III) complex [99gTc(S2CPh)(S3CPh) 2] 1 has been characterized both in solid and solution states at ground level, and found to be identical by HPLC concordance experiments with the corresponding Tc-99m agent prepared at carrier free level. The latter displays significant biological properties being able to label in vitro leukocytes in whole blood with high yields. The established mixed coordination sphere of 1, which is isostructural to the third-row rhenium complex [Re(S2CPh)(S3CPh)2] 2, comprises a dithiobenzoate and two perthiobenzoate fragments in a distorted trigonal prismatic arrangement. Redox behaviors indicate that the technetium complex is easier to reduce and more difficult to oxidize than the rhenium analog. The knowledge of the molecular structure of these new sulfur rich species makes now possible to improve their biological activity by subtly tuning the substituents on the dithiobenzoate fragments. |
| Databáze: | OpenAIRE |
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