Prediction of the Seizure Suppression Effect by Electrical Stimulation via a Computational Modeling Approach
| Autor: | Hyang Woon Lee, Sumin Jo, Sora Ahn, Sang Beom Jun, Seungjun Lee |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Neuroscience (miscellaneous) Phase (waves) Field effect Stimulation Neurotransmission Signal lcsh:RC321-571 electrical field effect 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine seizure suppression electrical stimulation computational model invitro experiment seizure propagation mechanism lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research Physics Communication Noise (signal processing) business.industry Seizure suppression 030104 developmental biology Transmission (telecommunications) in vitro experiment business Biological system 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Frontiers in Computational Neuroscience FRONTIERS IN COMPUTATIONAL NEUROSCIENCE(11) Frontiers in Computational Neuroscience, Vol 11 (2017) |
| ISSN: | 1662-5188 |
| Popis: | In this paper, we identified factors that can affect seizure suppression via electrical stimulation by an integrative study based on experimental and computational approach. Preferentially, we analyzed the characteristics of seizure-like events (SLEs) using our previous in vitro experimental data. The results were analyzed in two groups classified according to the size of the effective region, in which the SLE was able to be completely suppressed by local stimulation. However, no significant differences were found between these two groups in terms of signal features or propagation characteristics (i.e., propagation delays, frequency spectrum, and phase synchrony). Thus, we further investigated important factors using a computational model that was capable of evaluating specific influences on effective region size. In the proposed model, signal transmission between neurons was based on two different mechanisms: synaptic transmission and the electrical field effect. We were able to induce SLEs having similar characteristics with differentially weighted adjustments for the two transmission methods in various noise environments. Although the SLEs had similar characteristics, their suppression effects differed. First of all, the suppression effect occurred only locally where directly received the stimulation effect in the high noise environment, but it occurred in the entire network in the low noise environment. Interestingly, in the same noise environment, the suppression effect was different depending on SLE propagation mechanism; only a local suppression effect was observed when the influence of the electrical field transmission was very weak, whereas a global effect was observed with a stronger electrical field effect. These results indicate that neuronal activities synchronized by a strong electrical field effect respond more sensitively to partial changes in the entire network. In addition, the proposed model was able to predict that stimulation of a seizure focus region is more effective for suppression. In conclusion, we confirmed the possibility of a computational model as a simulation tool to analyze the efficacy of deep brain stimulation (DBS) and investigated the key factors that determine the size of an effective region in seizure suppression via electrical stimulation. |
| Databáze: | OpenAIRE |
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