Antigen-driven C–C Chemokine-mediated HIV-1 Suppression by CD4+ T Cells from Exposed Uninfected Individuals Expressing the Wild-type CCR-5 Allele
| Autor: | Renato Longhi, Samuele E. Burastero, Patrizia Loverro, Adriano Lazzarin, Lucinda Furci, Emily Carrow, Paolo Lusso, Davide Gaffi, Caroline Quillent, Gabriella Scarlatti, Antonio G. Siccardi, Barbara Borgonovo, Mauro S. Malnati, Claudia Colognesi, Alberto Beretta, Giuseppe Tambussi |
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| Rok vydání: | 1997 |
| Předmět: |
CD4-Positive T-Lymphocytes
Chemokine Genotype Receptors CCR5 Anti-HIV Agents T cell Molecular Sequence Data Immunology HIV Envelope Protein gp120 Lymphocyte Activation Virus Replication Receptors HIV Immune system Antigen medicine Humans Immunology and Allergy Cytotoxic T cell Amino Acid Sequence Receptors Cytokine Alleles biology Brief Definitive Report Wild type virus diseases Beta Chemokine Virology Chemokine Receptor Gene Clone Cells medicine.anatomical_structure HIV-1 biology.protein Brief Definitive Reports Chemokines Peptides |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.186.3.455 |
| Popis: | Despite repeated exposure to HIV-1, certain individuals remain persistently uninfected. Such exposed uninfected (EU) people show evidence of HIV-1–specific T cell immunity and, in rare cases, selective resistance to infection by macrophage-tropic strains of HIV-1. The latter has been associated with a 32–base pair deletion in the C–C chemokine receptor gene CCR-5, the major coreceptor of macrophage-tropic strains of HIV-1. We have undertaken an analysis of the HIV-specific T cell responses in 12 EU individuals who were either homozygous for the wild-type CCR-5 allele or heterozygous for the deletion allele (CCR-5Δ32). We have found evidence of an oligoclonal T cell response mediated by helper T cells specific for a conserved region of the HIV-1 envelope. These cells produce very high levels of C–C chemokines when stimulated by the specific antigen and suppress selectively the replication of macrophage-tropic, but not T cell–tropic, strains of HIV-1. These chemokine-producing helper cells may be part of a protective immune response that could be potentially exploited for vaccine development. |
| Databáze: | OpenAIRE |
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