Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
| Autor: | Baoli Hu, Massimo Squatrito, Nikunj Satani, Eskil Eskilsson, Jian Hu, Charles Etienne Gabriel Sauvé, Mitchel S. Berger, Emmanuel Martinez-Ledesma, Roel G.W. Verhaak, Hoon Kim, Amy B. Heimberger, Yan Li, Siyuan Zheng, Konrad Gabrusiewicz, Do Hyun Nam, Joanna J. Phillips, Ronald A. DePinho, Hee Jin Cho, Floris P. Barthel, Edward I. Chang, Gaetano Finocchiaro, Florian L. Muller, Zheng D. Lan, Adriana Olar, Qianghu Wang, Ana C. deCarvalho, Pengping Li, Erik P. Sulman, Tom Mikkelsen, Guocan Wang, Sali Lyu, Yu Hsi Lin, Lisa Scarpace, Xin Hu |
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| Přispěvatelé: | Neurosurgery |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research tumor evolution T-Lymphocytes 0302 clinical medicine Recurrence Gene expression Tumor Microenvironment 2.1 Biological and endogenous factors Aetiology Cancer Regulation of gene expression Microglia mesenchymal subtype Gene Expression Regulation Neoplastic medicine.anatomical_structure Phenotype Oncology 030220 oncology & carcinogenesis T cell Oncology and Carcinogenesis Biology Article 03 medical and health sciences disease recurrence immune cells Rare Diseases Glioma medicine Genetics Humans Oncology & Carcinogenesis macrophages/microglia Tumor microenvironment Neoplastic Gene Expression Profiling glioblastoma Neurosciences Cell Biology Gene signature medicine.disease Survival Analysis Brain Disorders Gene expression profiling proneural to mesenchymal transition Brain Cancer 030104 developmental biology Gene Expression Regulation Cancer cell Cancer research Glioblastoma CD8 |
| Zdroj: | Cancer cell, vol 32, iss 1 Cancer Cell, 33(1). Cell Press Wang, Q, Hu, B, Hu, X, Kim, H, Squatrito, M, Scarpace, L, deCarvalho, A C, Lyu, S, Li, P, Li, Y, Barthel, F, Cho, H J, Lin, Y-H, Satani, N, Martinez-Ledesma, E, Zheng, S, Chang, E, Gabriel Sauvé, C-E, Olar, A, Lan, Z D, Finocchiaro, G, Phillips, J J, Berger, M S, Gabrusiewicz, K R, Wang, G, Eskilsson, E, Hu, J, Mikkelsen, T, DePinho, R A, Muller, F, Heimberger, A B, Sulman, E P, Nam, D-H & Verhaak, R G W 2018, ' Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment ', Cancer Cell, vol. 33, no. 1, pp. 152 . https://doi.org/10.1016/j.ccell.2017.12.012 |
| ISSN: | 1535-6108 |
| Popis: | We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical. Transcriptomic subtype multiplicity correlated with increased intratumoral heterogeneity and presence of tumor microenvironment. In silico cell sorting identified macrophages/microglia, CD4+ T lymphocytes, and neutrophils in the glioma microenvironment. NF1 deficiency resulted in increased tumor-associated macrophages/microglia infiltration. Longitudinal transcriptome analysis showed that expression subtype is retained in 55% of cases. Gene signature-based tumor microenvironment inference revealed a decrease in invading monocytes and a subtype-dependent increase in macrophages/microglia cells upon disease recurrence. Hypermutation at diagnosis or at recurrence associated with CD8+ Tcell enrichment. Frequency of M2 macrophages detection associated with short-term relapse after radiation therapy. |
| Databáze: | OpenAIRE |
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