Histone deacetylase inhibitor BL1521 induces a G1-phase arrest in neuroblastoma cells through altered expression of cell cycle proteins
| Autor: | Annemieke J.M. de Ruijter, Chris van Bree, André B.P. van Kuilenburg, Huib N. Caron, Krista Ouwehand |
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| Přispěvatelé: | Cancer Center Amsterdam, Radiotherapy, Amsterdam Public Health, Paediatric Oncology, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases |
| Jazyk: | angličtina |
| Předmět: |
Cell Survival
medicine.drug_class Biophysics Cell Cycle Proteins Apoptosis Cell cycle Hydroxamic Acids Biochemistry Histone Deacetylases Neuroblastoma Downregulation and upregulation Structural Biology Cyclin-dependent kinase Cell Line Tumor Genetics medicine Humans Enzyme Inhibitors Molecular Biology neoplasms Cell Nucleus Histone deacetylase inhibitor biology G1 arrest Chemistry G1 Phase Retinoblastoma protein Cell Biology Cell biology Gene Expression Regulation Neoplastic Histone Deacetylase Inhibitors Cyclin dependent kinase inhibitor Trichostatin A biology.protein Cancer research Histone deacetylase medicine.drug |
| Zdroj: | FEBS letters, 579(6), 1523-1528. Wiley-Blackwell |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2005.01.058 |
| Popis: | Histone deacetylase inhibitors (HDACi) have been discovered as potential drugs for cancer treatment. The effect of BL1521, a novel HDACi, on the cell cycle distribution and the induction of apoptosis was investigated in a panel of MYCN single copy and MYCN amplified neuroblastoma cell lines. BL1521 arrested neuroblastoma cells in the G1 phase and induced up to 30% apoptosis. Downregulation of CDK4, upregulation of p21(WAF1/CIP1) and an increase of hypophosphorylated retinoblastoma protein were observed, indicating a possible mechanism for the cell-cycle arrest. BL1521 also induced down-regulation of p27, which may underlie the observed induction of apoptosis. (C) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies |
| Databáze: | OpenAIRE |
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