Linking Pre-Diabetes with Benign Prostate Hyperplasia. IGFBP-3: A Conductor of Benign Prostate Hyperplasia Development Orchestra?
| Autor: | Chrysoula Kyprianidou, Theodoros N. Sergentanis, Kostantinos Tzirogiannis, Achilles Ploumidis, Athanasia K. Papazafiropoulou, Andreas Melidonis, Padelis Constantoulakis, Dimitrios Delakas, Ioannis Protopsaltis |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Waist medicine.medical_treatment Prostatic Hyperplasia Urology lcsh:Medicine Real-Time Polymerase Chain Reaction Prediabetic State Impaired glucose tolerance Prostate Internal medicine medicine Humans lcsh:Science Aged Aged 80 and over Multidisciplinary medicine.diagnostic_test Prostatectomy business.industry lcsh:R Middle Aged Hyperplasia medicine.disease Impaired fasting glucose Insulin-Like Growth Factor Binding Protein 3 Endocrinology medicine.anatomical_structure Multivariate Analysis Transrectal ultrasonography lcsh:Q Waist Circumference Metabolic syndrome business Research Article |
| Zdroj: | PLoS ONE, Vol 8, Iss 12, p e81411 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Benign prostatic hyperplasia (BPH) represents a pattern of non-malignant growth of prostatic fibromuscular stroma. Metabolic disturbances such us pre-diabetes and metabolic syndrome may have a role in BPH pathophysiology. A potential explanation for the above relationship involves the insulin-like growth factor (IGF) axis as well as IGF binding proteins, (IGFBPs) of which the most abundant form is IGFBP-3. Therefore, the aim of the present study was to investigate the association between intra-prostatic levels of IGF-1, IGF-2 as well as to evaluate the role of locally expressed IGFBP-3 in BPH development in pre-diabetes. A total of 49 patients admitted to the Urology department of a tertiary urban Greek hospital, for transurethral prostate resection, or prostatectomy and with pre-diabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) or both] were finally included. The majority of the sample consisted of subjects with IGT (51.0%), followed by IFG and IGT (32.7%) and isolated IFG (16.3%). For all participants a clinical examination was performed and blood samples were collected. In addition, total prostate (TP) volume or transitional zone (TZ) volume were estimated by transrectal ultrasonography. The results of the multivariate analysis regarding TP volume showed that higher PSA (p |
| Databáze: | OpenAIRE |
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