The Effect of Adalimumab Treatment on Linear Growth in Children With Crohn Disease: A Post-hoc Analysis of the PAILOT Randomized Control Trial
| Autor: | Raanan Shamir, Baruch Yerushalmi, Ron Shaoul, Efrat Broide, Firas Rinawi, Amit Assa, Raffi Lev-Zion, Shlomi Cohen, Chani Topf-Olivestone, Oren Ledder, Batia Weiss, M Matar, Anat Guz-Mark |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Blood Sedimentation Standard score law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Crohn Disease Interquartile range law 030225 pediatrics Internal medicine Post-hoc analysis Adalimumab medicine Humans Child medicine.diagnostic_test business.industry Crohn disease Remission Induction Gastroenterology Treatment Outcome Erythrocyte sedimentation rate Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology Female business Body mass index medicine.drug |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 71(2) |
| ISSN: | 1536-4801 |
| Popis: | OBJECTIVES Growth impairment is common in children with Crohn disease (CD). We aimed to assess the effect of adalimumab (ADL) treatment on linear growth in children with CD in a post-hoc analysis of the Pediatric Crohn's Disease AdalImumab Level-based Optimization Treatment randomized controlled trial. METHODS Children 6 to 17 years who responded to ADL induction were assessed consecutively for anthropometric parameters. Associations of these parameters with disease characteristics and disease activity were analyzed. RESULTS Overall, 66 patients completed 72 weeks of follow-up (25% girls, mean age of 15.6 ± 2.5 years). Median (interquartile range [IQR]) height z score improved from -0.6 (-1.6-0.15) at baseline to -0.33 (-1.3-0.5) at week 72 (P = 0.005) with lesser improvement in patients with perianal disease. Similar effect was noted in children with growth potential (boys younger than 16 years, girls younger than 14 years). Median (IQR) height velocity standard deviation was -0.32 (-1.5-0.8) at week 26, and +0.11 (-1.1-1.3) at week 72. Median weight z score increased from -0.54 (-1.2-0.15) to -0.1 (-0.9-0.6), P |
| Databáze: | OpenAIRE |
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