Prophylactic effect of methylprednisolone against cisplatin-induced nephrotoxicity in rats
| Autor: | Uozumi Jiro, Kumazawa Joichi, Koikawa Yasuhiro, Ueda Toyofumi, Yasumasu Tetsuo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Injections Subcutaneous Pharmacology Toxicology Kidney Methylprednisolone Nephrotoxicity Blood Urea Nitrogen Rats Sprague-Dawley chemistry.chemical_compound Cisplatin induced nephrotoxicity Internal medicine medicine Animals Drug Interactions Cisplatin Cisplatin Injection Creatinine business.industry General Medicine Single injection Rats Steroid hormone Endocrinology chemistry Injections Intravenous business medicine.drug |
| Zdroj: | Toxicology letters. 66(3) |
| ISSN: | 0378-4274 |
| Popis: | Male Sprague-Dawley rats were intravenously injected with 6.5 mg/kg of cisplatin combined with a subcutaneous methylprednisolone (MP) injection to study the prophylactic effects of steroid hormone on cisplatin-induced nephrotoxicity. In Expt. 1, the rats were injected twice with either 10, 20 or 50 mg/kg of MP 4 and 0 h prior to the cisplatin injection and in Expt. 2, they were given a single injection of 100 mg/kg of MP either 24, 4, 2 or 0 h prior to the cisplatin injection. In Expt. 1, elevations of the BUN and serum creatinine levels caused by the cisplatin were dose-dependently inhibited by the administration of MP. In the second experiment, BUN and serum creatinine levels in rats which were pretreated with MP 4 or 2 h prior to the cisplatin injection were significantly lower than those in rats which received cisplatin alone. Our preliminary results suggest that pretreatment with MP is an effective means of protection against cisplatin-induced nephrotoxicity. |
| Databáze: | OpenAIRE |
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