Growth and Development in White Patients with Sickle Cell Diseases
Autor: | Piera Samperi, C. Consalvo, M. Mancuso, G. Spadaro, Gino Schilirò, M. Caruso-Nicoletti |
---|---|
Rok vydání: | 1992 |
Předmět: |
Microbiology (medical)
Sickle Hemoglobin Sickle cell trait medicine.medical_specialty business.industry Thalassemia Physiology Bone age Hematology medicine.disease Sickle cell anemia Surgery Adult women Infectious Diseases Hemoglobinopathy Skeletal maturation Oncology Pediatrics Perinatology and Child Health Menarche medicine business Sickle Cell Diseases Normal range |
Zdroj: | Journal of Pediatric Hematology/Oncology. 14:285-288 |
ISSN: | 1077-4114 |
DOI: | 10.1097/00043426-199211000-00002 |
Popis: | We have evaluated height, weight, bone age, somatomedin-C levels, and pubertal development in 114 Sicilian patients affected by sickle cell diseases (SCDs). Thirty-one had homozygous sickle hemoglobin (SS), 55 S-beta 0 thalassemia, and 28 S-beta + thalassemia. In both children and adults, the mean height and weight were approximately 1 SD below the normal mean for age. The height was below the normal range only in a few subjects (8 children and 4 adult women). Somatomedin-C levels were within the normal range in most of the patients (37/44 children and 17/22 adults). Bone age revealed a slight delay in skeletal maturation (mean chronological age and bone age were 7.7 +/- 3 and 7.11 +/- 2.9 respectively; p < 0.05). Mean age at menarche was increased compared to normal subjects. Our findings show that Sicilian patients with SCD exhibit a moderate delay of growth and adolescence but attain a final height within the normal range. |
Databáze: | OpenAIRE |
Externí odkaz: |