Pharmacophoric 2-hydroxyalkyl benzenesulfonamide: A single-step synthesis from benzenesulfonamide via hemiaminal
| Autor: | Krishnamurthi Vyas, Sunil Kumar Singh, K. Ravi Ganesh, R. Vasudev, Y. Koteswar Rao, K. Srinivas Rao, Javid Iqbal, J. Moses Babu, P. Praveen Kumar, V. Saibaba, S. Shivaramakrishna |
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| Rok vydání: | 2007 |
| Předmět: |
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Molecular Pharmacology chemistry.chemical_classification Aldehydes Sulfonamides Molecular Structure Bicyclic molecule Stereochemistry Chemistry Pharmaceutical Organic Chemistry Single step General Medicine Chemical synthesis Sulfonamide chemistry.chemical_compound chemistry Drug Design Alkanes Drug Discovery Hemiaminal Carbonic Anhydrase Inhibitors Oxidation-Reduction gamma-Aminobutyric Acid |
| Zdroj: | European Journal of Medicinal Chemistry. 42:456-462 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2006.09.021 |
| Popis: | ortho-Acylation attempt of benzenesulfonamide afforded the corresponding hemiaminal as major product. The in situ reduction of the reaction mixture, reported herein, directly provided 2-hydroxyalkyl benzenesulfonamide, an important pharmacophoric element for designing drug-like scaffolds. Its application is demonstrated through designing a novel series of 1,5-diarylpyrazoles for cyclooxygenase-2 (COX-2) inhibition. |
| Databáze: | OpenAIRE |
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