Clinical doses of radiation reduce collagen matrix stiffness
| Autor: | Matthew R. Zanotelli, Cynthia A. Reinhart-King, Brandon Borde, Lawrence J. Bonassar, Danielle J. LaValley, Joseph Miller, Francois Bordeleau, Susan C. Pannullo, Dylan J. Parker |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:Medical technology Chemistry lcsh:Biotechnology Biomedical Engineering Biophysics Motility Bioengineering Adhesion Invited Articles In vitro Ionizing radiation Biomaterials Extracellular matrix 03 medical and health sciences 030104 developmental biology 0302 clinical medicine lcsh:R855-855.5 In vivo lcsh:TP248.13-248.65 030220 oncology & carcinogenesis Special Topic: Bioengineering of Cancer Cancer cell Ex vivo |
| Zdroj: | APL Bioengineering APL Bioengineering, Vol 2, Iss 3, Pp 031901-031901-11 (2018) |
| ISSN: | 2473-2877 |
| Popis: | Cells receive mechanical cues from their extracellular matrix (ECM), which direct migration, differentiation, apoptosis, and in some cases, the transition to a cancerous phenotype. As a result, there has been significant research to develop methods to tune the mechanical properties of the ECM and understand cell-ECM dynamics more deeply. Here, we show that ionizing radiation can reduce the stiffness of an ex vivo tumor and an in vitro collagen matrix. When non-irradiated cancer cells were seeded in the irradiated matrix, adhesion, spreading, and migration were reduced. These data have ramifications for both in vitro and in vivo systems. In vitro, these data suggest that irradiation may be a method that could be used to create matrices with tailored mechanical properties. In vivo, these suggest that therapeutic doses of radiation may alter tissue mechanics directly. |
| Databáze: | OpenAIRE |
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