Bronchopulmonary infection with Mycobacterium malmoense presenting as a bronchoesophageal fistula
| Autor: | E. Hasper, Berndt Lüderitz, Santiago Ewig, Kai Wilhelm, H. Schäfer, E. Pakoš |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Immunology Opportunistic Infections Microbiology Mycobacterium malmoense Esophageal Fistula Immunocompromised Host Clarithromycin Pneumonia Bacterial medicine Humans Bronchial Biopsy Ethambutol Immunodeficiency Aged Mycobacterium Infections biology medicine.diagnostic_test business.industry biology.organism_classification medicine.disease respiratory tract diseases Radiography Pneumonia Treatment Outcome Bronchoalveolar lavage Sputum Bronchial Fistula medicine.symptom business medicine.drug |
| Zdroj: | Tubercle and Lung Disease. 77:287-290 |
| ISSN: | 0962-8479 |
| DOI: | 10.1016/s0962-8479(96)90016-7 |
| Popis: | We report a bronchopulmonary infection with Mycobacterium malmoense in a patient with severe immunosuppression due to insulin-dependent diabetes mellitus, humoral immunodeficiency after thymoma (Good's syndrome) and prolonged immunosuppressive treatment after myasthenic crisis. It presented as non-resolving pneumonia of the left lower lobe. Bronchoscopically, a bronchoesophageal fistula was detected. Numerous acid-fast organisms were found in the sputum specimen and in the bronchial biopsy around the fistula. M. malmoense was isolated from sputum, bronchoalveolar lavage and bronchial biopsy. Whereas conventional in vitro susceptibility testing revealed susceptibility only to ethambutol, multi-drug susceptibility testing confirmed susceptibility to rifampicin, ethambutol, clarithromycin and prothionamide. The clinical outcome after 12 months of therapy resulted in a stable remission and considerable suppression of the mycobacterial load, but not in complete eradication. |
| Databáze: | OpenAIRE |
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