The clinical influence of the preoperative lymphocyte‐to‐monocyte ratio on the postoperative outcome of patients with early‐stage gastrointestinal cancer

Autor: Shozo Mori, Mitsuru Ishizuka, Kazutoshi Takagi, Keiichi Kubota, Yukihiro Iso, Yuhki Sakuraoka, Akihito Abe, Takayuki Shimizu, Takayuki Shiraki, Taku Aoki
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Annals of Gastroenterological Surgery, Vol 4, Iss 5, Pp 580-590 (2020)
Annals of Gastroenterological Surgery
ISSN: 2475-0328
Popis: Aim The lymphocyte‐to‐monocyte ratio (LMR) is useful for predicting the prognosis of patients with gastric cancer (GC) and those with colorectal cancer (CRC) undergoing surgery. The relationship between the LMR and postoperative outcome of patients with early‐stage gastrointestinal cancers such as stage I GC and CRC remains unclear. Methods We retrospectively evaluated 323 stage I GC and 152 stage I CRC patients undergoing surgery. Univariate and multivariate analyses using the Cox proportional hazards model were performed to identify the clinical characteristics associated with overall survival (OS), and the cut‐off values of these variables were determined by receiver operating characteristic analysis. The Kaplan–Meier method and log‐rank test were used for postoperative survival comparisons according to the LMR (GC: LMR 75/≤75 years) (HR, 3.511; 95% CI, 1.881‐6.551; P 3.5 g/dL) (HR, 3.040; 95% CI, 1.575‐5.869; P = 0.001), in stage I GC patients. Survival analysis demonstrated a significantly poorer OS in stage I GC patients with a LMR
Relationship between cumulative infectious disease and lymphocyte‐to‐monocyte ratio in patients with early stage gastrointestinal cancer after surgery. (a) Stage I gastric cancer and (b) Stage I colorectal cancer.
Databáze: OpenAIRE
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