Amphiphilic copolymers in biomedical applications: Synthesis routes and property control
| Autor: | Francesca Perin, Antonella Motta, Devid Maniglio |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Click crosslinking Biocompatibility Polymers Amphiphilic polymers Property (programming) Injectable hydrogels Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Self-assembling polymers Biomaterials Drug Delivery Systems Smart polymer synthesis Amphiphile Humans Amphiphilic polymers Smart polymer synthesis Self-assembling polymers Click crosslinking Click coupling Smart drug delivery Stimuli responsive polymers Precision biomaterials Click coupling chemistry.chemical_classification Tissue Engineering Smart drug delivery Stimuli responsive polymers Hydrogels Polymer Precision biomaterials 021001 nanoscience & nanotechnology 0104 chemical sciences 3. Good health chemistry Targeted drug delivery Mechanics of Materials Drug delivery 0210 nano-technology Amphiphilic copolymer |
| Zdroj: | Materials Science and Engineering: C |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2021.111952 |
| Popis: | The request of new materials, matching strict requirements to be applied in precision and patient-specific medicine, is pushing for the synthesis of more and more complex block copolymers. Amphiphilic block copolymers are emerging in the biomedical field due to their great potential in terms of stimuli responsiveness, drug loading capabilities and reversible thermal gelation. Amphiphilicity guarantees self-assembly and thermoreversibility, while grafting polymers offers the possibility of combining blocks with various properties in one single material. These features make amphiphilic block copolymers excellent candidates for fine tuning drug delivery, gene therapy and for designing injectable hydrogels for tissue engineering. This manuscript revises the main techniques developed in the last decade for the synthesis of amphiphilic block copolymers for biomedical application. Strategies for fine tuning the properties of these novel materials during synthesis are discussed. A deep knowledge of the synthesis techniques and their effect on the performance and the biocompatibility of these polymers is the first step to move them from the lab to the bench. Current results predict a bright future for these materials in paving the way towards a smarter, less invasive, while more effective, medicine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect