3-Azido-3-deoxy-glycopyranoside derivatives as scaffolds for the synthesis of carbohydrate-Based universal pharmacophore mapping libraries

Autor:	Muthoni G. Kamau, Chunguang Wang, Rakesh K. Jain, Huiming Wang, Michael J. Sofia, Richard G. Dulina, Robert Ippolito, David Gange, Jan A. Anderson
Rok vydání:	2003
Předmět:	Azides Light Stereochemistry Carboxylic acid Clinical Biochemistry Carboxylic Acids Pharmaceutical Science Uronic acid Hydroxylation Biochemistry Chemical synthesis Mass Spectrometry chemistry.chemical_compound Drug Discovery Combinatorial Chemistry Techniques Scattering Radiation Monosaccharide Glycosides Molecular Biology chemistry.chemical_classification Fluorenes Monosaccharides Organic Chemistry Glycoside chemistry Aldose Molecular Medicine Indicators and Reagents Azide Pharmacophore Chromatography Liquid
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:2185-2189
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(03)00384-6
Popis:	The regiospecific syntheses of six monosaccharide scaffolds, 1 – 6 , containing a carboxylic acid, an azido and a free hydroxyl group were accomplished through the utilization of a key intermediate, namely, methyl 3-azido-3-deoxy-β- d -glucopyranoside ( 10 ). Scaffold 2 was also used in generating combinatorial libraries using solid-phase methodologies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7110adb51866809082e64164c5cc4e06 https://doi.org/10.1016/s0960-894x(03)00384-6 Zobrazit plný text záznamu Full Text from ScienceDirect