Peripheral vascular disease in Type 2 diabetic Chinese patients: associations with metabolic indices, concomitant vascular disease and genetic factors
| Autor: | J. A. J. H. Critchley, G. N. Thomas, C. S. Cockram, Brian Tomlinson, Juliana C.N. Chan |
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| Rok vydání: | 2003 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism Angiotensinogen Blood Pressure Type 2 diabetes Peptidyl-Dipeptidase A Receptor Angiotensin Type 1 Renin-Angiotensin System Endocrinology Gene Frequency Albumins Internal medicine Diabetes mellitus Internal Medicine medicine Humans Triglycerides Aged Peripheral Vascular Diseases Polymorphism Genetic biology medicine.diagnostic_test Vascular disease business.industry Cholesterol HDL Angiotensin-converting enzyme Cholesterol LDL medicine.disease Angiotensin II Cholesterol Blood pressure Diabetes Mellitus Type 2 Cardiovascular Diseases Creatinine biology.protein Hong Kong Female Metabolic syndrome business Lipid profile Diabetic Angiopathies Gene Deletion |
| Zdroj: | ResearcherID |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1046/j.1464-5491.2003.01046.x |
| Popis: | Aims Conventional and genetic risk factors have been reported to play a role in the pathogenesis of vascular disease, but do not explain the lower burden of cardiac and peripheral vascular disease (PVD) in Chinese compared with Caucasians. The role of renin-angiotensin system (RAS) gene polymorphisms and conventional vascular risk factors has not been determined. Methods A total of 3097 Chinese diabetic subjects were screened for PVD, which was identified in 194 of the 2967 patients with Type 2 diabetes. Biochemical parameters and the genotype and allele frequencies of three RAS gene polymorphisms, the angiotensin-converting enzyme (ACE) insertion/deletion, angiotensinogen (AGT) M235T and angiotensin II type 1 receptor (AT1R) A1166C polymorphisms were then compared between the PVD patients and 1046 age, gender and diabetes duration-matched patients without PVD. Results PVD identified in 6.5% was associated with significantly worse glycaemic control, lipid profile and renal function. Smoking was more common, as were the other macro- and microvascular diseases. The prevalence of hypertension was similar between the groups, yet diastolic blood pressure was slightly lower in the PVD group. The ACE D allele was significantly more frequent in patients with PVD compared with the matched diabetic controls (38.1 vs. 29.8%, P = 0.039). No differences in the AT1R or AGT polymorphisms were observed. Conclusions PVD was associated with a worse metabolic profile and greater concomitant vascular disease than controls. The ACE I/D polymorphism was associated with PVD in these Type 2 diabetic patients. Diabet. Med. 20, ***–*** (2003) |
| Databáze: | OpenAIRE |
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