Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis

Autor:	Fei Li, Feng Cao, Yulin Guo, Chen Li, Huaxia Yang, Shaoyou Xia
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Abdominal pain medicine.medical_specialty APACHE II Article Subject RC86-88.9 business.industry Mortality rate Medical emergencies. Critical care. Intensive care. First aid 030208 emergency & critical care medicine Cochrane Library medicine.disease Gastroenterology Continuous hemofiltration 03 medical and health sciences 0302 clinical medicine Meta-analysis Internal medicine Emergency Medicine medicine Acute pancreatitis 030211 gastroenterology & hepatology medicine.symptom Prospective cohort study business Research Article
Zdroj:	Emergency Medicine International, Vol 2020 (2020) Emergency Medicine International
ISSN:	2090-2840
DOI:	10.1155/2020/6474308
Popis:	Background. Severe acute pancreatitis (SAP) is a deadly condition, with a mortality rate ranging from 15% to 30%. Recently, blood purification therapy has been adopted in administrating SAP patients. The present study aimed at evaluating the effect of continuous hemofiltration therapy for SAP. Methods. A systematic search of Cochrane Library, PubMed, and Embase was carried out until October 1st, 2019. Prospective studies comparing outcomes for SAP patients between continuous hemofiltration and standard therapy were enrolled. Results. Continuous hemofiltration therapy was associated with lower level of PACHE II score (MD = −1.49; 95% CI: −2.69 to −0.29, P=0.02), CRP (MD = −1.56 mg/L; 95% CI: −2.64 to −0.47, P=0.005), Cr (MD = −3.57 umol/L; 95% CI: −5.50 to −1.65, P=0.003), and Bun (MD = −3.63 mmol/L; 95% CI: −6.07 to −1.20, P=0.003) at 72 h after onset of treatment. Continuous hemofiltration therapy was associated with shorter length of abdominal pain relief time (MD = −1.82 hours; 95% CI: −2.93 to −0.71, P=0.001), lower surgery rate (OR = 0.15; 95% CI: 0.03 to 0.78, P=0.02), and mortality rate (OR = 0.54; 95% CI: 0.37 to 0.77, P=0.0007). Conclusions. continuous hemofiltration therapy could effectively alleviate SAP as early as 72 hours after onset of treatment, lowering the level of Bun, Cr, CRP, and APACHE II scores. Continuous hemofiltration therapy could confer SAP patients with lower mortality rates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710f290e9a76243402c4d2a5b7e55a55 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.