Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and Fluorescence Spectroscopies
| Autor: | Roya Mohammadi-Meyabadi, Negar Beirampour, Núria Garrós, Helen Lissette Alvarado, David Limón, Marcelle Silva-Abreu, Ana Cristina Calpena, Mireia Mallandrich |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Sistemes d'alliberament de medicaments
Solubility baricitinib poorly water-soluble drug solubility study stability study in vitro tissue uptake fluorescence spectroscopy absorption spectroscopy drug recovery drug uptake Pharmaceutical Science Solubilitat Fluorescència Fluorescence Drug delivery systems |
| Zdroj: | Pharmaceutics; Volume 14; Issue 12; Pages: 2714 |
| ISSN: | 1999-4923 |
| DOI: | 10.3390/pharmaceutics14122714 |
| Popis: | The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in different solvents, including Transcutol, a biocompatible permeation enhancer that is miscible in water, to evaluate the drug uptake in human skin and porcine tissues (sclera, cornea, oral, sublingual, and vaginal), and to subsequently extract the drug from the tissues so as to determine the drug recovery using in vitro techniques. Analytical methods were developed and validated for the quantification of BCT in Transcutol using absorption and fluorescence spectroscopies, which are complementary to each other and permit the detection of the drug across a broad range of concentrations. Results show that Transcutol permits an increased drug solubility, and that BCT is able to penetrate the tissues studied. The solutions of BCT in Transcutol were stable for at least one week. Hence, Transcutol may be a suitable solvent for further development of topical formulations. |
| Databáze: | OpenAIRE |
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