Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age

Autor: Hannah Crossland, Matthew S. Brook, Jonathan I. Quinlan, Martino V. Franchi, Bethan E. Phillips, Daniel J. Wilkinson, Constantinos N. Maganaris, Paul L. Greenhaff, Nathaniel J. Szewczyk, Kenneth Smith, Marco V. Narici, Philip J. Atherton
Rok vydání: 2022
Předmět:
Zdroj: GeroScience. 45:331-344
ISSN: 2509-2723
2509-2715
Popis: Exercise training can induce adaptive changes to tendon tissue both structurally and mechanically; however, the underlying compositional changes that contribute to these alterations remain uncertain in humans, particularly in the context of the ageing tendon. The aims of the present study were to determine the molecular changes with ageing in patellar tendons in humans, as well as the responses to exercise and exercise type (eccentric (ECC) and concentric (CON)) in young and old patellar tendon. Healthy younger males (age 23.5 ± 6.1 years; n = 27) and older males (age 68.5 ± 1.9 years; n = 27) undertook 8 weeks of CON or ECC training (3 times per week; at 60% of 1 repetition maximum (1RM)) or no training. Subjects consumed D2O throughout the protocol and tendon biopsies were collected after 4 and 8 weeks for measurement of fractional synthetic rates (FSR) of tendon protein synthesis and gene expression. There were increases in tendon protein synthesis following 4 weeks of CON and ECC training (P
Databáze: OpenAIRE
Externí odkaz: