Fabrication and Characterization of Core-Shell Electrospun Fibrous Mats Containing Medicinal Herbs for Wound Healing and Skin Tissue Engineering

Autor: Abdolreza Simchi, Elahe Zahedi, Niloofar Eslahi, Akbar Esmaeili, Mohammad Ali Shokrgozar
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Materials science
Aloe vera extract
Polymers
Polyesters
Nanofibers
Pharmaceutical Science
wound healing
02 engineering and technology
010402 general chemistry
01 natural sciences
Article
Aloe vera
Contact angle
Chitosan
chemistry.chemical_compound
Tensile Strength
Materials Testing
Spectroscopy
Fourier Transform Infrared
Drug Discovery
Ultimate tensile strength
Aloe
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
lcsh:QH301-705.5
co-axial electrospinning
Skin
Plants
Medicinal
Tissue Engineering
Tissue Scaffolds
biology
Adhesion
021001 nanoscience & nanotechnology
biology.organism_classification
Electrospinning
0104 chemical sciences
Chemical engineering
chemistry
lcsh:Biology (General)
polysaccharide
Polycaprolactone
Microscopy
Electron
Scanning
core-shell fiber
0210 nano-technology
Wound healing
Zdroj: Marine Drugs, Vol 17, Iss 1, p 27 (2019)
Marine Drugs
Volume 17
Issue 1
ISSN: 1660-3397
Popis: Nanofibrous structures mimicking the native extracellular matrix have attracted considerable attention for biomedical applications. The present study aims to design and produce drug-eluting core-shell fibrous scaffolds for wound healing and skin tissue engineering. Aloe vera extracts were encapsulated inside polymer fibers containing chitosan, polycaprolactone, and keratin using the co-axial electrospinning technique. Electron microscopic studies show that continuous and uniform fibers with an average diameter of 209 ±
47 nm were successfully fabricated. The fibers have a core-shell structure with a shell thickness of about 90 nm, as confirmed by transmission electron microscopy. By employing Fourier-transform infrared spectroscopy, the characteristic peaks of Aloe vera were detected, which indicate successful incorporation of this natural herb into the polymeric fibers. Tensile testing and hydrophilicity measurements indicated an ultimate strength of 5.3 MPa (elongation of 0.63%) and water contact angle of 89°
In-vitro biological assay revealed increased cellular growth and adhesion with the presence of Aloe vera without any cytotoxic effects. The prepared core-shell fibrous mats containing medical herbs have a great potential for wound healing applications.
Databáze: OpenAIRE
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