Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors

Autor:	Hiroshi Morimoto, Tsuguo Ikebe, Atsushi Fukunari, Yoichi Naka, Takanori Oe, Ichimaro Yamada, Seigo Ishibuchi, Hiroyoshi Inoue, Miho Kamezawa
Rok vydání:	2001
Předmět:	Male Xanthine Oxidase Gout Urate Oxidase Allopurinol Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Gout Suppressants Rats Sprague-Dawley chemistry.chemical_compound Structure-Activity Relationship Metabolic Diseases Drug Discovery medicine Structure–activity relationship Animals Hyperuricemia Xanthine oxidase Molecular Biology chemistry.chemical_classification biology Organic Chemistry medicine.disease Rats Uric Acid Enzyme chemistry Enzyme inhibitor Area Under Curve Models Animal biology.protein Molecular Medicine Uric acid Pyrazoles medicine.drug
Zdroj:	Bioorganicmedicinal chemistry letters. 11(7)
ISSN:	0960-894X
Popis:	A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7106faab40971656ad68c7636cf3101a https://pubmed.ncbi.nlm.nih.gov/11294382 Zobrazit plný text záznamu Full Text from ScienceDirect