FGFs in endochondral skeletal development
| Autor: | William A. Horton, Catherine Degnin, Melanie B. Laederich |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Distal clavicle
Biology Fibroblast growth factor Models Biological Biochemistry Bone and Bones Osteogenesis medicine Animals Humans Growth Plate Molecular Biology Endochondral ossification Bone Development Cell Biology Anatomy Receptors Fibroblast Growth Factor Skeleton (computer programming) Fibroblast Growth Factors Skull medicine.anatomical_structure Fibroblast growth factor receptor Clavicle Intramembranous ossification Neuroscience Signal Transduction |
| Zdroj: | Journal of Cellular Biochemistry. 110:1046-1057 |
| ISSN: | 0730-2312 |
| DOI: | 10.1002/jcb.22629 |
| Popis: | The mammalian skeleton developments and grows through two complementary pathways: membranous ossification, which gives rise to the calvarial bones and distal clavicle, and endochondral ossification, which is responsible for the bones of the limbs, girdles, vertebrae, face and base of the skull and the medial clavicle. Fibroblast growth factors (FGFs) and their cognate FGF receptors (FGFRs) play important roles in regulating both pathways. However, the details of how FGF signals are initiated, propagated and modulated within the developing skeleton are only slowly emerging. This prospect will focus on the current understanding of these events during endochondral skeletal development with special attention given to concepts that have emerged in the past few years. |
| Databáze: | OpenAIRE |
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