Arrhythmic gut microbiome signatures predict risk of type 2 diabetes
| Autor: | Eduardo L. Almeida, Jordana T. Bell, Annette Peters, Wolfgang Rathmann, Jan Baumbach, Thomas Clavel, Paul W. O'Toole, Tarini Shankar Ghosh, Klaus Neuhaus, Caroline I. Le Roy, Harald Grallert, Taylor A. Breuninger, Beate Brandl, Markus List, Sandra Reitmeier, Martina Troll, Dirk Haller, Matthias Laudes, Silke Kiessling, Andre Franke, Hans Hauner, Birgit Linkohr, Thomas Skurk, Tim D. Spector, Jakob Linseisen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Genetics
0303 health sciences endocrine system diseases nutritional and metabolic diseases Type 2 diabetes Biology medicine.disease Microbiology Obesity Gut microbiome 03 medical and health sciences 0302 clinical medicine Metagenomics Virology Gut bacteria Cohort medicine Parasitology Microbiome Circadian rhythm ddc:610 030217 neurology & neurosurgery 030304 developmental biology |
| Popis: | Lifestyle, obesity, and the gut microbiome are important risk factors for metabolic disorders. We demonstrate in 1,976 subjects of a German population cohort (KORA) that specific microbiota members show 24-h oscillations in their relative abundance and identified 13 taxa with disrupted rhythmicity in type 2 diabetes (T2D). Cross-validated prediction models based on this signature similarly classified T2D. In an independent cohort (FoCus), disruption of microbial oscillation and the model for T2D classification was confirmed in 1,363 subjects. This arrhythmic risk signature was able to predict T2D in 699 KORA subjects 5 years after initial sampling, being most effective in combination with BMI. Shotgun metagenomic analysis functionally linked 26 metabolic pathways to the diurnal oscillation of gut bacteria. Thus, a cohort-specific risk pattern of arrhythmic taxa enables classification and prediction of T2D, suggesting a functional link between circadian rhythms and the microbiome in metabolic diseases. |
| Databáze: | OpenAIRE |
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