Pseudoguaianelactones A–C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2
| Autor: | Hui Cui, Shiqin Jiang, Bao Yang, Yuqian Tang, Zhongxiang Zhao, Jing Jin, Tao Yi, Qingfeng Ruan, Xiao-Yun Zheng |
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| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
medicine.drug_class Anti-Inflammatory Agents Molecular Conformation Nitric Oxide Synthase Type II Crystallography X-Ray Nitric Oxide 010402 general chemistry Sesquiterpene Plant Roots 01 natural sciences Catalysis Anti-inflammatory Nitric oxide Mice chemistry.chemical_compound Materials Chemistry Ic50 values medicine Animals Moiety RAW 264.7 Cells chemistry.chemical_classification Lindera glauca 010405 organic chemistry Macrophages Metals and Alloys General Chemistry Lindera Molecular biology 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Enzyme chemistry Cyclooxygenase 2 Ceramics and Composites Cytokines Sesquiterpenes |
| Zdroj: | Chemical Communications. 56:1517-1520 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c9cc09159a |
| Popis: | The pseudoguaianelactones A (1) and B (2), two novel sesquiterpene lactones with an unprecedented [5,7,7] ring system featuring an α-methylene-γ-lactone moiety, together with a new pseudoguaianelactone C (3) were isolated from the roots of Lindera glauca. Pseudoguaianelactones A-C (1-3) inhibited nitric oxide (NO) production, with IC50 values ranging from 1.38 to 4.00 μM. Moreover, all compounds significantly suppressed the production of pro-inflammatory mediators (TNF-α, IL-6, IL-1β and PGE2) and the protein expression of the enzymes iNOS and COX-2. |
| Databáze: | OpenAIRE |
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