Clinical effects of nitrendipine on variant angina pectoris
| Autor: | Seiichi Toyama, Takashi Yanaga, Hiroshi Kishida, Keiko Suzuki, Kazuzo Kato, Masao Ikeda |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Angina Pectoris
Variant Male Chemotherapy Pretreatment Period Variant angina pectoris business.industry medicine.medical_treatment Nitrendipine Antagonist Anginal attacks Middle Aged medicine.disease Angina Anesthesia Ambulatory medicine Electrocardiography Ambulatory Humans Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Japanese heart journal. 32(3) |
| ISSN: | 0021-4868 |
| Popis: | The clinical effects of nitrendipine, a new calcium antagonist, were investigated in a single-blind test on 21 patients with variant angina pectoris. The efficacy of the drug was evaluated on the basis of frequency of anginal attacks and Holter electrocardiographic findings during different treatment periods at doses of 10 mg once a day (period I) and 20 mg once a day (period II). The number of anginal attacks decreased significantly from a pretreatment level of 2.1 +/- 0.3 per day to 0.7 +/- 0.2 per day in treatment period I and 0.3 +/- 0.1 per day in treatment period II (p less than 0.01, p less than 0.001, respectively). The consumption of sublingual nitroglycerin tablets decreased significantly in both treatment periods in comparison with the observation period before treatment (p less than 0.01, p less than 0.001, respectively). In 20 patients with continuous ECG monitoring, the frequency of ST-segment elevation was 4.5 +/- 1.0 per day during the pretreatment period; it decreased significantly to 0.9 +/- 0.6 per day in treatment period I and 0.5 +/- 0.3 per day in treatment period II (p less than 0.01, p less than 0.001, respectively). The duration and the maximum magnitude of ST-segment elevation also improved significantly in both treatment periods. These results demonstrate the efficacy of nitrendipine in the treatment of variant angina at a single daily dose of 10 mg. |
| Databáze: | OpenAIRE |
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