Gadolinium chloride inhibits Kupffer cell nitric oxide synthase (iNOS) induction
| Autor: | Bashoo Naziruddin, C. R. Roland, Thalachallour Mohanakumar, M W Flye |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Lipopolysaccharides
Male Lipopolysaccharide Calmodulin Kupffer Cells Phagocytosis Gadolinium Immunology chemistry.chemical_element Dinoprostone Rats Sprague-Dawley chemistry.chemical_compound Western blot In vivo Transforming Growth Factor beta medicine Immunology and Allergy Animals Cells Cultured biology medicine.diagnostic_test Kupffer cell Cell Biology Molecular biology Rats Nitric oxide synthase medicine.anatomical_structure chemistry Enzyme Induction biology.protein Nitric Oxide Synthase |
| Zdroj: | Journal of leukocyte biology. 60(4) |
| ISSN: | 0741-5400 |
| Popis: | Kupffer cells (KC) are the phagocytic macrophages of the liver. The rare earth metal, gadolinium (GdCl3), is a lanthanide, which, after phagocytosis by the KC, has been found to alter various aspects of KC physiology. In this study, we describe for the first time that the in vivo administration of GdCl3 to rate decreases the release of NO by isolated rat KC in response to lipopolysaccharide. Western blot analysis shows decreased expression of both imlucible nitric oxide synthase as well as total cellular calmodulin after GdCl3 treatment. Possible mechanisms for this phenomenon are suggested. |
| Databáze: | OpenAIRE |
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