Patient-reported flare frequency is associated with diminished quality of life and family role functioning in systemic lupus erythematosus
| Autor: | Lauren Topf, Michael L. Reed, Ryan Bostic, Patricia P. Katz, Paola Daly, Erin Connolly-Strong, George J. Wan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Family functioning Role functioning Lupus nephritis Severity of Illness Index law.invention Quality of life law Surveys and Questionnaires Internal medicine medicine Humans Lupus Erythematosus Systemic Patient Reported Outcome Measures skin and connective tissue diseases Aged Systemic lupus erythematosus Multivariable linear regression business.industry Role Public Health Environmental and Occupational Health Middle Aged Symptom Flare Up medicine.disease Linear Models Quality of Life Female Family Relations Analysis of variance business Flare |
| Zdroj: | Quality of Life Research. 29:3251-3261 |
| ISSN: | 1573-2649 0962-9343 |
| Popis: | To understand the influence of the systemic lupus erythematosus (SLE)-related flares on patient’s health-related quality of life (HRQoL). An online survey included individuals with self-reported physician’s diagnosis of SLE or lupus nephritis (LN). Lupus impact tracker (LIT) assessed lupus symptoms and HRQoL, SLE-Family questionnaire measured family role functioning, and Healthy Days Core Module (HDCM) measured overall mental and physical health. Chi-square and analysis of variance evaluated differences by flare frequency. Multivariable linear regression and generalized linear models evaluated the independent relationships of flare frequency to HRQoL. 1066 respondents with SLE or LN completed the survey. Mean (SD) duration of illness was 12.4 (10.1) years. 93.4% (n = 996) were women, 82.3% (n = 830) were White, and 49.7% (n = 530) were employed or students. More frequent flares were associated with significantly worse scores on all HRQoL measures: LIT (adjusted means: 0 flares, 31.8; 1–3 flares, 47.0; 4–6 flares, 56.1; ≥ 7 flares, 63.6; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |