Effects of a selective ET(A)-receptor antagonist, atrasentan (ABT-627), in murine models of allergic asthma: demonstration of mouse strain specificity
| Autor: | Bruno Battistini, Mélanie Gosselin, Louis-Philippe Boulet, Stéphanie Goulet, Jinshyun R. Wu-Wong, Terry J. Opgenorth, Jerry L. Wessale |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.hormone
Endothelin Receptor Antagonists Male Pyrrolidines Antineoplastic Agents Endothelins Leukocyte Count Mice Species Specificity Medicine Animals Lymphocyte Count Receptor Sensitization Mice Inbred BALB C biology business.industry Atrasentan Respiratory disease General Medicine respiratory system medicine.disease Receptor Endothelin A Asthma Eosinophils Mice Inbred C57BL Ovalbumin medicine.anatomical_structure Immunology Models Animal biology.protein Bronchoconstriction medicine.symptom Antagonism business Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | Clinical science (London, England : 1979). 103 |
| ISSN: | 0143-5221 |
| Popis: | Asthma is a chronic respiratory disease that is characterized by airway inflammation, bronchoconstriction and the influx of pro-inflammatory cells, mostly eosinophils in the lung tissue and bronchoalveolar space. Amongst the many physiopathological roles attributed to endothelins (ETs), one is to modulate pulmonary functions. It is established that Balb/c mice develop allergen-induced Th2-cytokine gene expression, airway inflammation and hyper-responsiveness whereas C57Bl/6 mice are much less reactive. In the present study, we investigated the roles of ETs in these two murine models of allergic asthma (AA). Mice were sensitized and challenged with either saline (S) and/or ovalbumin (O) over 6 weeks (groups S/S and O/O) and treated chronically with ABT-627 or its vehicle. Twenty-four hours after the last sensitization, challenged mice developed a marked airway inflammatory response characterized by the accumulation of total inflammatory cells (a 21-fold increase) in the bronchoalveolar space, similar in both mouse strains. The increase in eosinophils was marked in both groups, representing 98% of total cell count in O/O versus |
| Databáze: | OpenAIRE |
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