Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin
| Autor: | Xi-Miao Hou, Peng-Ye Wang, Xu-Guang Xi, Shuo-Xing Dou, Jing You, Hai-Peng Ju, Yi-Zhou Wang, Wei Li |
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| Přispěvatelé: | University of Science and Technology of China [Hefei] (USTC), Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Multi-disciplinary Materials Research Center, Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Magnetic tweezers Dna duplex [SDV]Life Sciences [q-bio] General Chemical Engineering Kinetics Biology 010402 general chemistry G-quadruplex 01 natural sciences Article lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound medicine heterocyclic compounds ComputingMilieux_MISCELLANEOUS Cisplatin General Chemistry 0104 chemical sciences 3. Good health Folding (chemistry) 030104 developmental biology lcsh:QD1-999 Biochemistry chemistry Chemotherapy Drugs DNA medicine.drug |
| Zdroj: | ACS Omega ACS Omega, ACS Publications, 2016, 1 (2), pp.244-250. ⟨10.1021/acsomega.6b00044⟩ ACS Omega, Vol 1, Iss 2, Pp 244-250 (2016) |
| ISSN: | 2470-1343 |
| Popis: | G-Quadruplex DNA structure has been proven to be a binding target for small molecular organic compounds and hence regarded as a promising pharmacological target. Cisplatin is a widely used chemotherapy drug that targets duplex DNA and was recently shown to react also with G-quadruplex, implying that cisplatin actually may also target G-quadruplex. In this work, we employed magnetic tweezers to investigate the influence of cisplatin on the folding kinetics of single human telomeric G-quadruplex. It was revealed that cisplatin and G-quadruplex interact in two different and competitive ways that depend on cisplatin concentration. |
| Databáze: | OpenAIRE |
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