Acute and chronic optic nerve head biomechanics and intraocular pressure changes in patients receiving multiple intravitreal injections of anti-VEGF

Autor: Francisco J. Muñoz-Negrete, M Gómez-Mariscal, V. De Juan, Gema Rebolleda, B Puerto
Rok vydání: 2018
Předmět:
Male
Retinal Ganglion Cells
medicine.medical_specialty
Intraocular pressure
genetic structures
Recombinant Fusion Proteins
Optic Disk
Nerve fiber layer
Angiogenesis Inhibitors
Loading dose
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Nerve Fibers
Ophthalmology
Ranibizumab
medicine
Humans
In patient
Prospective cohort study
Aged
Retrospective Studies
Aged
80 and over
business.industry
Biomechanics
Retinal
Middle Aged
eye diseases
Sensory Systems
medicine.anatomical_structure
Receptors
Vascular Endothelial Growth Factor
chemistry
Acute Disease
Chronic Disease
Intravitreal Injections
030221 ophthalmology & optometry
Optic nerve
Wet Macular Degeneration
Female
sense organs
business
030217 neurology & neurosurgery
Tomography
Optical Coherence
Follow-Up Studies
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 257(10)
ISSN: 1435-702X
Popis: To evaluate acute and chronic changes in optic nerve head (ONH) structures and intraocular pressure (IOP) in patients receiving intravitreal injections (IVIs) of anti-VEGF. Twenty-nine eyes receiving IVIs for the first time were studied. IOP, retinal nerve fiber layer (RNFL) thickness, and ONH structures were evaluated by Spectralis optical coherence tomography with enhanced depth imaging technology. Structures were measured before and 5 min after each one of the three monthly injections of a loading dose treatment. In 13 eyes (44.8%) with more than six IVIs, another evaluation pre and immediately postinjection was performed after 1 year. A significant acute and transient IOP increase (all p ≤ 0.001), Bruch’s membrane opening (BMO) enlargement (p ≤ 0.001), cup widening (p
Databáze: OpenAIRE
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