Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models
| Autor: | Isha Kumbam, Pilar Montes-Lourido, Manaswini Kar, Srivatsun Sadagopan |
|---|---|
| Přispěvatelé: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Centro de Estudos de Doenças Crónicas (CEDOC) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Science media_common.quotation_subject Auditory oddball Guinea Pigs Stimulus (physiology) Audiology Affect (psychology) Pupil Article 03 medical and health sciences 0302 clinical medicine Perception medicine Animals Humans Attention General media_common Multidisciplinary Auditory Threshold Organ Size Audiometry Evoked Response 030104 developmental biology Acoustic Stimulation Models Animal Medicine Auditory system Female Sensory processing Metric (unit) sense organs Vocalization Animal Psychology 030217 neurology & neurosurgery Pupillometry |
| Zdroj: | Scientific Reports Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Estimates of detection and discrimination thresholds are often used to explore broad perceptual similarities between human subjects and animal models. Pupillometry shows great promise as a non-invasive, easily-deployable method of comparing human and animal thresholds. Using pupillometry, previous studies in animal models have obtained threshold estimates to simple stimuli such as pure tones, but have not explored whether similar pupil responses can be evoked by complex stimuli, what other stimulus contingencies might affect stimulus-evoked pupil responses, and if pupil responses can be modulated by experience or short-term training. In this study, we used an auditory oddball paradigm to estimate detection and discrimination thresholds across a wide range of stimuli in guinea pigs. We demonstrate that pupillometry yields reliable detection and discrimination thresholds across a range of simple (tones) and complex (conspecific vocalizations) stimuli; that pupil responses can be robustly evoked using different stimulus contingencies (low-level acoustic changes, or higher level categorical changes); and that pupil responses are modulated by short-term training. These results lay the foundation for using pupillometry as a high-throughput method of estimating thresholds in large experimental cohorts, and unveil the full potential of using pupillometry to explore broad similarities between humans and animal models. |
| Databáze: | OpenAIRE |
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