Adaptive disinhibitory gating by VIP interneurons permits associative learning
Autor: | Yael Bitterman, Francesco Ferraguti, Sabine Krabbe, Jan Gründemann, Milica Markovic, Keisuke Yonehara, Chun Xu, Simon D’Aquin, Andreas Lüthi, Enrica Paradiso |
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Rok vydání: | 2018 |
Předmět: |
0303 health sciences
Interneuron Computer science Vasoactive intestinal peptide Gating Optogenetics Inhibitory postsynaptic potential Associative learning 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Calcium imaging nervous system medicine Excitatory postsynaptic potential Fear conditioning Neuroscience 030217 neurology & neurosurgery 030304 developmental biology Basolateral amygdala |
Popis: | Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during associative learning is studied extensively, little is known about the contributions of local interneurons. Using fear conditioning as a model for associative learning, we find that behaviorally relevant, salient stimuli cause learning by tapping into a local microcircuit consisting of precisely connected subtypes of inhibitory interneurons. By employing calcium imaging and optogenetics, we demonstrate that vasoactive intestinal peptide (VIP)-expressing interneurons in the basolateral amygdala are activated by aversive events and provide an instructive disinhibitory signal for associative learning. Notably, VIP interneuron responses are plastic and shift from the instructive to the predictive cue upon memory formation. We describe a novel form of adaptive disinhibitory gating by VIP interneurons that allows to discriminate unexpected, important from irrelevant information, and might be a general dynamic circuit motif to trigger stimulus-specific learning, thereby ensuring appropriate behavioral adaptations to salient events. |
Databáze: | OpenAIRE |
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