Time-dependent miR-16 serum fluctuations together with reciprocal changes in the expression level of miR-16 in mesocortical circuit contribute to stress resilient phenotype in chronic mild stress - An animal model of depression

Autor: Dariusz Zurawek, Kinga Szafran-Pilch, Magdalena Kolasa, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka, M. Kusmider, Piotr Gruca, Mariusz Papp, Joanna Solich, Paulina Pabian
Rok vydání: 2015
Předmět:
0301 basic medicine
Nervous system
Male
Anhedonia
stress resilience
chemistry.chemical_compound
Random Allocation
0302 clinical medicine
Limbic system
Corticosterone
Dietary Sucrose
Limbic System
Pharmacology (medical)
Melatonin
microRNA
Resilience
Psychological
Phenotype
Psychiatry and Mental health
medicine.anatomical_structure
Neurology
depression
biomarker
medicine.symptom
Psychology
medicine.drug
medicine.medical_specialty
Mesocortical pathway
Time
03 medical and health sciences
Internal medicine
medicine
Animals
Rats
Wistar
Biological Psychiatry
Pharmacology
Depressive Disorder
chronic mild stress
Feeding Behavior
rats
Disease Models
Animal
MicroRNAs
030104 developmental biology
Endocrinology
chemistry
Chronic Disease
Neurology (clinical)
030217 neurology & neurosurgery
Biomarkers
Stress
Psychological
Zdroj: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26(1)
ISSN: 1873-7862
Popis: MicroRNAs (miRNAs) are involved in stress-related pathologies. However, the molecular mechanisms underlying stress resilience are elusive. Using chronic mild stress (CMS), an animal model of depression, we identified animals exhibiting a resilient phenotype. We investigated serum levels of corticosterone, melatonin and 376 mature miRNAs to find peripheral biomarkers associated with the resilient phenotype. miR-16, selected during screening step, was assayed in different brain regions in order to find potential relationship between brain and peripheral alterations in response to stress. Two CMS experiments that lasted for 2 and 7 consecutive weeks were performed. During both CMS procedures, sucrose consumption levels were significantly decreased in anhedonic-like animals (p
Databáze: OpenAIRE
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