Gestational atrazine exposure: effects on male reproductive development and metabolite distribution in the dam, fetus, and neonate
| Autor: | Deborah S. Best, Ralph L. Cooper, Alaa Kamel, Lori K. Davis, Michelle G. Hotchkiss, Michael G. Narotsky, Gary R. Klinefelter, Tammy E. Stoker, Jerome M. Goldman, Lynda V. Podhorniak, Yaorong Qian, Melanie J.P. Fraites |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Offspring Metabolite Physiology Biology Genitalia Male Toxicology Fetal Development Rats Sprague-Dawley chemistry.chemical_compound Fetus Internal medicine Testis medicine Distribution (pharmacology) Animals Testosterone Atrazine Behavior Animal Herbicides Reproduction Rats Endocrinology chemistry Animals Newborn In utero Maternal Exposure Gestation Female |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 32(1) |
| ISSN: | 1873-1708 |
| Popis: | Few studies have investigated the long-term effects of atrazine (ATR) following in utero exposure. We evaluated the effects of gestational exposure of Sprague Dawley dams to ATR (0, 1, 5, 20, or 100mg/kg-d) on the reproductive development of male offspring. We also quantified the distribution of ATR and its chlorinated metabolites in maternal, fetal, and neonatal fluid and tissue samples following gestational and/or lactational exposure. Dose-dependent levels of chlorotriazines, primarily diamino-s-chlorotriazine, were present in most samples analyzed, including fetal tissue. In utero exposure to 1-20mg/kg-d ATR did not alter testosterone production, the timing of puberty, play behavior, or other androgen-dependent endpoints of male offspring. Significant maternal toxicity and postnatal mortality were observed at 100mg/kg-d. We conclude that, although levels of chlorotriazines within the fetus were considerable, gestational exposures of 1-20mg/kg-d do not lead to alterations in the measures of male development examined in this study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect