Impact of swimming exercise on inflammation in medullary areas of sympathetic outflow control in spontaneously hypertensive rats
| Autor: | Patrícia Taranto, Rui M. B. Maciel, Bruno Hamermesz, Eduardo M. Cafarchio, Andréa Vancetto Maglione, Cristiana A. Ogihara, Gisele Giannocco, Monica Akemi Sato, Janaina Sena de Souza |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Inflammation Blood Pressure medicine.disease_cause Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Heart Rate Internal medicine Physical Conditioning Animal Rats Inbred SHR Heart rate medicine Animals cardiovascular diseases Rats Wistar Swimming computer.programming_language Medulla Oblongata sed Chemistry Solitary tract Rostral ventrolateral medulla Rats Oxidative Stress 030104 developmental biology Endocrinology Blood pressure Neuroglobin cardiovascular system Cytokines Neurology (clinical) medicine.symptom Reactive Oxygen Species computer 030217 neurology & neurosurgery Oxidative stress circulatory and respiratory physiology |
| Zdroj: | Metabolic brain disease. 33(5) |
| ISSN: | 1573-7365 |
| Popis: | Exercise reduces sympathetic activity (SA), arterial pressure and heart rate in spontaneously hypertensive rats (SHR). Exercise increases oxidative stress (OS) and inflammation is implicated in the generation of reactive oxygen species (ROS) and progression of hypertension. To unravel these effects of exercise and considering that SA is driven by medullary areas, we hypothesized that swimming exercise (SW) affects the gene expression (g.e.) of proteins involved in inflammation and OS in the commissural Nucleus of the Solitary Tract (cNTS) and Rostral ventrolateral medulla (RVLM), which control the sympathetic outflow in SHR. We used male SHR and Wistar rats (14-16wks-old) which were maintained sedentary (SED) or submitted to SW (1 h/day, 5 days/wk./6wks). The g.e. of cycloxygenase-2 (COX-2), interleukin 6 (IL-6), interleukin 10 (IL-10), AT-1 receptor (AT-1r), neuroglobin (Ngb) and cytoglobin (Ctb) in cNTS and RVLM was carried out by qPCR. We observed that COX-2 g.e. increased in SW-SHR in cNTS and RVLM compared to SED-SHR. The IL-6 g.e. reduced in RVLM in SW-SHR, whereas IL-10 g.e. increased in SW-SHR in comparison to SED-SHR. The AT-1r g.e. decreased in SW-SHR in cNTS and RVLM compared to SED-SHR. The Ngb and Ctb g.e. in cNTS neurons increased in SHR and Wistar rats submitted to SW compared to SED, but only Ctb g.e. increased in RVLM in SW-SHR and Wistar in comparison to SED. Therefore, the SW altered the g.e. in cNTS and RVLM for reducing the inflammation and ROS formation, which is increased particularly in SHR, consequently decreasing the OS. |
| Databáze: | OpenAIRE |
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