Age-related differences in antibody avidities to pertussis toxin and filamentous hemagglutinin in a healthy Japanese population
| Autor: | Kazunari Kamachi, Tomimasa Sunagawa, Hajime Kamiya, Keiko Tanaka-Taya, Rei Fumimoto, Nao Otsuka |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Adolescent Whooping Cough Antibody Affinity Immunization Secondary Filamentous haemagglutinin adhesin chemical and pharmacologic phenomena Pertussis toxin Young Adult 03 medical and health sciences 0302 clinical medicine Japan 030225 pediatrics Age related Humans Medicine Avidity 030212 general & internal medicine Child Pertussis Vaccine General Veterinary General Immunology and Microbiology biology business.industry Vaccination Age Factors Public Health Environmental and Occupational Health Antibody titer Infant Middle Aged Japanese population Antibodies Bacterial Healthy Volunteers Hemagglutinins Infectious Diseases Pertussis Toxin Child Preschool Immunoglobulin G Immunology biology.protein Molecular Medicine Female Antibody business |
| Zdroj: | Vaccine. 37:2463-2469 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2019.03.055 |
| Popis: | To gain insights into the current Japanese pertussis immunization schedule, we examined the distributions of antibody titers and avidities to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in 460 Japanese healthy subjects (aged 1-60 years) based on age category. Our avidity enzyme-linked immunosorbent assays revealed that young children aged 1-2 years, which corresponded to ages after receiving primary and/or booster pertussis vaccinations, had relatively high-avidity anti-PT IgG (mean avidity index [AI], 40.5%) compared with other age groups (AI, 26.5-31.9%); however, they had relatively low-avidity anti-FHA IgG (AI, 41.8%). In contrast, children aged 3-6 years had both low-avidity anti-PT IgG (AI, 26.5%) and low-avidity anti-FHA IgG (AI, 40.4%). A significant age-related difference in anti-PT IgG avidity was observed between children aged 1-2 years and 3-6 years (P < 0.05); however, the difference in anti-FHA IgG avidity was not significant. The anti-PT IgG avidity was positively correlated with the antibody titer, especially among children aged 1-15 years (rs = 0.508-0.685; P < 0.01), indicating that the avidity of vaccine-induced anti-PT IgG decreases with decreasing IgG antibody titer to PT. Our findings strongly suggest that vaccine-induced anti-PT IgG avidity rapidly wanes after vaccination, but this is not observed for anti-FHA IgG avidity. Because children aged 3-6 years have both low-quantity and low-quality antibodies against PT, an additional booster vaccination with acellular pertussis vaccines is required for such children in Japan. |
| Databáze: | OpenAIRE |
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