Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users
| Autor: | Iulia Niculescu, Dan Otelea, Andrea-Clemencia Pineda-Peña, Pieter Libin, Ana B. Abecasis, Raluca Jipa, Marta Pingarilho, Leontina Banica, Emil Neaga, Adrian Abagiu, Simona Paraschiv, Kristof Theys, Ionelia Nicolae |
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| Přispěvatelé: | Instituto de Higiene e Medicina Tropical (IHMT), Global Health and Tropical Medicine (GHTM), TB, HIV and opportunistic diseases and pathogens (THOP), Informatics and Applied Informatics, Faculty of Sciences and Bioengineering Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
European People Epidemiology Hepacivirus HIV Infections HEPATITIS-C Pathology and Laboratory Medicine Disease Outbreaks 0302 clinical medicine Immunodeficiency Viruses Ethnicities Drug use lcsh:Science Phylogeny education.field_of_study Human immunodeficiency virus Coinfection Prison virus diseases Phylogenetic Analysis Romanian People Medical Microbiology HIV epidemiology Viral Pathogens Infectious diseases Human medicine.medical_specialty Genotype Bioinformatics Epidemic Major clinical study Biochemistry Genetics and Molecular Biology (miscellaneous) Microbiology Article Virus transmission 03 medical and health sciences SDG 3 - Good Health and Well-being HIGH PREVALENCE Human immunodeficiency virus infection Genetics Pathogenicity Transmission Humans Evolutionary Systematics education Microbial Pathogens Ecology Evolution Behavior and Systematics Molecular epidemiology SEQUENCES Romanian (citizen) lcsh:R Organisms Outbreak Biology and Life Sciences medicine.disease Virology 030104 developmental biology Population Groupings lcsh:Q Nucleotide sequence 0301 basic medicine RNA viruses lcsh:Medicine Drug Users Database and Informatics Methods Medicine and Health Sciences Mixed infection 030212 general & internal medicine Data Management RISK Multidisciplinary biology Transmission (medicine) Molecular clock HIV diagnosis and management Hepatitis C Phylogenetics Infectious Diseases Drug dependence Viruses Female SPREAD Pathogens Sequence Analysis Research Article Adult Computer and Information Sciences Population VIRUS-INFECTION Viral diseases Research and Analysis Methods MOLECULAR EPIDEMIOLOGY PEOPLE Retroviruses Journal Article medicine Taxonomy Evolutionary Biology business.industry Romania Lentivirus HIV biology.organism_classification GENOTYPES Diagnostic medicine People and Places SUBTYPE F1 business Controlled study Viral Transmission and Infection |
| Zdroj: | PLoS ONE, Vol 12, Iss 10, p e0185866 (2017) PLoS ONE Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 1932-6203 |
| Popis: | Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to characterize and compare transmission dynamics of the two viruses. Three large HIV clusters (2 subtype F1 and one CRF14_BG) and thirteen smaller HCV transmission networks (genotypes 1a, 1b, 3a, 4a and 4d) were identified. Eighty (65%) patients were both in HIV and HCV transmission chains and 70 of those shared the same HIV and HCV cluster with at least one other patient. Molecular clock analysis indicated that all identified HIV clusters originated around 2006, while the origin of the different HCV clusters ranged between 1980 (genotype 1b) and 2011 (genotypes 3a and 4d). HCV infection preceded HIV infection in 80.3% of cases. Coincidental transmission of HIV and HCV was estimated to be rather low (19.65%) and associated with an outbreak among PWID during detention in the same penitentiary. This study has reconstructed and compared the dispersion of these two viruses in a PWID population. © 2017 Paraschiv et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Databáze: | OpenAIRE |
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