Can dynamic and static pupillary responses be used as an indicator of autonomic dysfunction in patients with obstructive sleep apnea syndrome?
| Autor: | Seyfettin Erdem, Mehmet Fuat Alakus, Uğur Keklikçi, Süreyya Yilmaz, Sedat Ava, Mehmet Dursun, Mine Karahan |
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| Přispěvatelé: | Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı, Erdem, Seyfettin, Yılmaz, Süreyya, Karahan, Mine, Dursun, Mehmet Emin, Ava, Sedat, Keklikçi, Uğur |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Mesopic vision Autonomic dysfunction Diabetic autonomic neuropathy Pupil 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Pupillary response Humans Diabetic Autonomic Neuropathy Sleep Apnea Obstructive business.industry medicine.disease respiratory tract diseases Obstructive sleep apnea Obstructive sleep apnea syndrome Ophthalmology Autonomic nervous system Autonomic Nervous System Diseases Pupillometry 030221 ophthalmology & optometry Cardiology sense organs business 030217 neurology & neurosurgery Photopic vision |
| Zdroj: | International Ophthalmology. 41:2555-2563 |
| ISSN: | 1573-2630 0165-5701 |
| DOI: | 10.1007/s10792-021-01814-0 |
| Popis: | WOS:000632380600003 PMID: 33763793 Purpose We aimed to reveal whether static and dynamic pupillary responses can be used for the detection of autonomic nervous system (ANS) dysfunction in patients with obstructive sleep apnea syndrome (OSAS). Methods We included in this study patients with OSAS, who were divided into three groups according to the apnea-hypopnea index (AHI) (group 1, mild [n = 20]; group 2, moderate [n = 20]; and group 3, severe [n = 20]), and healthy controls (group 4, n = 20). Pupillary responses were measured using a pupillometry system. Results Static (mesopic PD, P = 0.0019; low photopic PD, P = 0.001) and dynamic pupil responses (resting diameter, P = 0.004; amplitude of pupil contraction, P < 0.001; duration of pupil contraction, P = 0.022; velocity of pupil contraction, P = 0.001; and velocity of pupil dilation, P = 0.012) were affected in patients with different OSAS severities. Also, AHI was negatively correlated with mesopic PD (P = 0.008), low photopic PD (P = 0.003), resting diameter (P = 0.001), amplitude of pupil contraction (P < 0.001), duration of pupil contraction (P = 0.011), velocity of pupil contraction (P < 0.001), and velocity of pupil dilation (P = 0.001). Conclusion We detected pupil responses innervated by the ANS were affected in the OSAS patients. This effect was more significant in the severe OSAS patients. Therefore, the pupillometry system can be an easily applicable, noninvasive method to detect ANS dysfunction in the OSA patients. |
| Databáze: | OpenAIRE |
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