The Histocompatibility Complex of Rhesus Monkeys. II. A Major Locus Controlling Reactivity in Mixed Lymphocyte Cultures
| Autor: | H. Balner, E. K. Toth |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Genotype Lymphocyte Synthetic antigen Immunology chemical and pharmacologic phenomena Locus (genetics) Lymphocyte Activation Major histocompatibility complex Biochemistry Immune system Antigen Isoantibodies Histocompatibility Antigens Methods Genetics medicine Animals Immunology and Allergy Cytotoxic T cell Carbon Radioisotopes Lymphocytes Rh-Hr Blood-Group System biology Histocompatibility Testing Immune Sera fungi hemic and immune systems Haplorhini General Medicine Cytotoxicity Tests Immunologic Histocompatibility Phenotype medicine.anatomical_structure biology.protein Macaca Female Lymphocyte Culture Test Mixed Thymidine |
| Zdroj: | Tissue Antigens. 3:273-290 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1973.tb01005.x |
| Popis: | Rhesus monkeys have a genetic locus which has a major influence on reactivity in mixed lymphocyte cultures (MLR). This MLR locus is closely linked to the RhL–A system2, which controls the serologically defined histocompatibility antigens of this species. Three cases of recombination between RhL–A and the MLR region are described. Consequently, the MLR locus is located outside the RhL–A region proper, possibly adjacent to the locus defining the antigens of the 1st series. The recombination frequency between the MLR and RhL–A regions of rhesus monkeys is similar to that found for the analogous systems of man. Inhibition of MLR can be achieved by pre-incubation of responder or stimulator cells with cytotoxic anti-RhL–A sera. Such inhibition is highly specific and probably caused by an interaction of the sera with RhL–A surface antigens, not with MLR determinants. Yet, there is circumstantial evidence that non-cytotoxic sera can be produced which inhibit MLR, presumably by affecting MLR determinants on the cell surface. The relevance of MLR to histocompatibility and the genetic control of the immune response of rhesus monkeys to synthetic antigens, are the subjects of current studies which are briefly discussed. |
| Databáze: | OpenAIRE |
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