Zinc directly stimulates cholecystokinin secretion from enteroendocrine cells and reduces gastric emptying in rats
| Autor: | Hitoshi Iwaya, Shingo Nakajima, Tohru Hira, Hiroshi Hara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Enteroendocrine Cells Intracellular Space chemistry.chemical_element Enteroendocrine cell Gastric emptying Transient receptor potential ankyrin 1 (TRPA1) Zinc Calcium digestive system Biochemistry Models Biological Cell Line Rats Sprague-Dawley 03 medical and health sciences Mice Endocrinology Transient Receptor Potential Channels Internal medicine medicine Extracellular Animals Secretion Calcium Signaling Molecular Biology TRPA1 Cation Channel Cholecystokinin Chemistry digestive oral and skin physiology 030104 developmental biology Extracellular Space hormones hormone substitutes and hormone antagonists Intracellular |
| Zdroj: | Molecular and Cellular Endocrinology. 430:108-114 |
| ISSN: | 0303-7207 |
| Popis: | Zinc, an essential mineral element, regulates various physiological functions such as immune responses and hormone secretion. Cholecystokinin (CCK), a gut hormone, has a role in protective immunity through the regulation of gastrointestinal motility, appetite, and inflammatory response. Here, we examined the effect of zinc on CCK secretion in STC-1 cells, an enteroendocrine cell line derived from murine duodenum, and in rats. Extracellular zinc triggered CCK secretion accompanied with increased intracellular Ca(2+) and Zn(2+) mobilization in STC-1 cells. Zinc-induced CCK secretion was abolished in the absence of intracellular Zn(2+) or extracellular calcium. Upon inhibition of transient receptor potential ankyrin 1 (TRPA1), extracellular zinc failed to increase intracellular Ca(2+) and subsequent CCK secretion. In rats, oral zinc administration decreased gastric emptying through the activation of CCK signaling. These results suggest that zinc is a novel stimulant for CCK secretion through the activation of TRPA1 related to intracellular Zn(2+) and Ca(2+) mobilization. |
| Databáze: | OpenAIRE |
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