Human leukocyte antigen-G (HLA-G) expression in cervical cancer lesions is associated with disease progression
| Autor: | Xiang-Juan Li, Yan-Yun Ruan, Xia Zhang, Aifen Lin, Wei-Hua Yan |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Immunology Uterine Cervical Neoplasms Human leukocyte antigen Cervical intraepithelial neoplasia Young Adult HLA-G medicine Humans Immunology and Allergy Stage (cooking) Young adult Aged Neoplasm Staging HLA-G Antigens Cervical cancer Regulation of gene expression business.industry General Medicine Middle Aged medicine.disease Gene Expression Regulation Neoplastic Disease Progression Immunohistochemistry Female business |
| Zdroj: | Human Immunology. 73:946-949 |
| ISSN: | 0198-8859 |
| Popis: | The immunotolerant human leukocyte antigen (HLA)-G has direct inhibitory effects on natural killer cells, dendritic cells, T cells and can indirectly induce tolerant regulatory cells. The significance of the aberrant HLA-G expression in malignant contexts has been intensively investigated. In the current study, HLA-G expression in 22 normal cervical tissues, 14 cervical intraepithelial neoplasia (CIN) patients and 129 patients with squamous cell cervical cancer were examined using immunohistochemistry. The association of HLA-G expression with disease progression was calculated with the Pearson Chi-square test. It was found that HLA-G expression was absent in normal cervical tissues, and that HLA-G expression was increased from patients with CIN III (35.7%, 4/14) to patients with cervical cancer (62.8%, 81/129). Among the cervical cancer patients, HLA-G expression in FIGO stage I, II, and stage III+IV was 53.6% (45/84), 76.3% (29/38), and 100.0% (7/7), respectively. Taken together, our findings indicated that HLA-G expression was associated with the disease progression in patients with cervical cancer. |
| Databáze: | OpenAIRE |
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