Refusal of cancer-directed surgery in male breast cancer
| Autor: | Zeming Liu, Yihui Huang, Shipei Wang, Liang Guo, Chao Zhang, Di Hu, Sichao Chen, Wen Zeng, Min Wang, Ling Zhou, Wei Wei, Danyang Chen, Wei Zhou, Haifeng Feng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Observational Study male breast cancer Kaplan-Meier Estimate survival Breast Neoplasms Male surgery Treatment Refusal 03 medical and health sciences 0302 clinical medicine Risk Factors Epidemiology medicine Humans 030212 general & internal medicine Survival analysis Mastectomy Aged Neoplasm Staging Proportional Hazards Models Proportional hazards model business.industry the Surveillance Epidemiology and End Results Program Incidence (epidemiology) Incidence Hazard ratio Cancer General Medicine Middle Aged medicine.disease Confidence interval United States Surgery 030220 oncology & carcinogenesis Male breast cancer refusal business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | It has been reported that some male breast cancer patients may refuse the recommended surgery, but the incidence rate in the United States is not clear. The purpose of this study was to identify the incidence, trends, risk factors, and eventual survival outcomes associated with the rejection of such cancer-directed surgery. We collected data on 5860 patients with male breast cancer (MBC) from the Surveillance, Epidemiology, and End Results database, including 50 patients refusing surgery as recommended. Kaplan–Meier survival analysis and Cox proportional hazard regression were used to identify the effects of refusing surgery on cancer-specific survival (CSS) and overall survival (OS). The association between acceptance or rejection of surgery and mortality were estimated by nested Cox proportional hazards regression models with adjustment for age, race, clinical characteristics, and radiation. Of the 5860 patients identified, 50 (0.9%) refused surgery. Old age (≥65: hazard ratio [HR]: 3.056, 95% confidence interval [CI]: 1.738–5.374, P |
| Databáze: | OpenAIRE |
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