The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases:a systematic review and meta-analysis
| Autor: | Philipp Schuetz, Hugo J. Gale, Anne J. M. Loonen, Clark D Russell, Naomi S. Bulteel, Arun Parajuli, Georgios Merekoulias, J Kenneth Baillie, Cornelis P.C. de Jager |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Adolescent Neutrophils Lymphocyte Urinary system 030106 microbiology Bacteremia Communicable Diseases Monocytes Sepsis 03 medical and health sciences Leukocyte Count Young Adult 0302 clinical medicine Blood platelets Internal medicine Medicine Humans 030212 general & internal medicine Child Aged Aged 80 and over business.industry fungi Infant Newborn Endotypes Infant Pneumonia Stratified medicine Middle Aged medicine.disease Influenza Infectious Diseases medicine.anatomical_structure Meta-analysis Child Preschool Female business Malaria Biomarkers Respiratory tract |
| Zdroj: | Russell, C D, Parajuli, A, Gale, H J, Bulteel, N S, Schuetz, P, de Jager, C P C, Loonen, A J M, Merekoulias, G I & Baillie, J 2019, ' The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases : a systematic review and meta-analysis ', Journal of Infection . https://doi.org/10.1016/j.jinf.2019.02.006 |
| DOI: | 10.1016/j.jinf.2019.02.006 |
| Popis: | OBJECTIVES: To assess the utility of the neutrophil:lymphocyte (NLR), lymphocyte:monocyte (LMR) and platelet:lymphocyte ratios (PLR) as infection biomarkers.METHODS: PubMed/MEDLINE, Embase and Cochrane databases were searched to identify eligible articles. Studies of diagnosis, severity or outcome were included. PROSPERO systematic review registration CRD42017075032.RESULTS: Forty studies were included, reporting on bacterial and viral infections, malaria, and critical illness due to sepsis. Ten studies reported an association of higher NLR with bacteraemia, supported by meta-analysis of patient-level data (five studies, n=3320; AUC 0.72, p12.65. Two studies reported an association with lower LMR and diagnosis of influenza virus infection in patients with respiratory tract infection. Meta-analysis of patient-level data (n=85; AUC 0.66, p=0.01) identified a cut-off of ≤2.06. The directionality of associations between NLR and outcomes in heterogeneous cohorts of critically ill adults with sepsis varied. Potential clinical utility was also demonstrated in pneumonia (NLR), pertussis (NLR), urinary tract infection (NLR), diabetic foot infections (NLR) and Crimean Congo Haemorrhagic Fever (PLR). Longitudinal measurement of LMR during respiratory virus infection reflected symptoms and NLR during sepsis and bacteraemia predicted mortality.CONCLUSIONS: Peripheral blood leucocyte ratios are useful infection biomarkers, with the most evidence related to diagnosis of bacteraemia and influenza virus infection. In critical illness due to sepsis, a signal towards an association with NLR and outcomes exists, and NLR should be evaluated in future stratification models. Longitudinal measurement of ratios during infection could be informative. Overall, these biomarkers warrant further recognition and study in infectious diseases. |
| Databáze: | OpenAIRE |
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