Immuno-phenotype and proliferative response of B-cell chronic lymphocytic leukemia
| Autor: | J. S. Nadkarni, Sangeeta Karfa, Gopal R |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Cancer Research Chronic lymphocytic leukemia T cell B-Lymphocyte Subsets T-Lymphocytes Regulatory Immunoglobulin G Immunophenotyping Leukocyte Count T-Lymphocyte Subsets Tumor Cells Cultured Cytotoxic T cell Medicine Humans Aged Neoplasm Staging biology business.industry T-Lymphocytes Helper-Inducer Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell medicine.anatomical_structure Oncology Immunoglobulin M Immunology biology.protein Female CD5 business CD8 |
| Zdroj: | Medical oncology and tumor pharmacotherapy. 7(4) |
| ISSN: | 0736-0118 |
| Popis: | This study examines the immunophenotypic profiles in both pretreated and treated CLL patients which could be useful from the prognosis point of view. Patients suffering from B CLL and having IgG markers were relatively more aggressive than cells bearing IgM phenotypes. Male predominance is observed in male/female ratio in this disease. B CLL showed heterogeneity by showing reactivity against various T cell markers such as CD5 (present on mature T cells) and also CD4 (T helper/inducer), CD8 (T suppressor/cytotoxic) and a very high percentage of Ia (HLA-DR). The proliferative response to cells to stimulation with PHA and PWM indicated that there is a primary defect in the capacity of these small lymphocytes to undergo a proliferative response due to an intrinsic defect in the B lymphocytes. This study also reflects a maturation arrest in the later developmental stage of B lymphopoiesis. The three findings which are novel are the difference in prognosis between IgG-IgM and IgG, the changes in T cell subsets and the mitogenic response. |
| Databáze: | OpenAIRE |
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