GPER-1 expression decreases during breast cancer tumorigenesis
| Autor: | Atanas Ignatov, Serban-Dan Costa, Andrzej Semczuk, Thomas Kalinski, Antje Lemke, Christine Weißenborn, Angela Poehlmann, Tanja Ignatov, Albert Roessner |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty medicine.drug_class Gene Expression Breast Neoplasms Kaplan-Meier Estimate medicine.disease_cause Disease-Free Survival Receptors G-Protein-Coupled Breast cancer Risk Factors Internal medicine Carcinoma Medicine Humans Grading (tumors) Lymph node Aged Aged 80 and over business.industry Carcinoma Ductal Breast General Medicine Middle Aged medicine.disease Epithelium medicine.anatomical_structure Carcinoma Intraductal Noninfiltrating Cell Transformation Neoplastic Receptors Estrogen Estrogen Lymphatic Metastasis Multivariate Analysis Female Neoplasm Recurrence Local business Carcinogenesis GPER |
| Zdroj: | Cancer investigation. 31(5) |
| ISSN: | 1532-4192 |
| Popis: | GPER-1 protein expression was immunohistochemically examined in 164 primary breast cancer specimens and their matched normal breast epithelium. GPER-1 down-regulation correlated significantly with increased histological grading (p = .015), lymph node metastases (p = .032), and negative estrogen receptor status (p = .018). The decrease of GPER-1 expression in breast cancer tissue, relative to normal tissue, was associated with poor overall survival (p = .043) and disease-free survival (p = .037) and remained a significant unfavorable factor in multivariate analysis for DFS (HR = 1.569; 95% CI, 1.024–2.797; p = .041) and OS (HR = 2.082; 95% CI, 1.248–4.773; p = .039). Thus aberrant GPER-1 expression seems to be an important factor in breast cancer progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |